This is an event meant to make memories. Winning is cool, but when will you have an opportunity to race around a city, completing fun challenges, pushing yourself mentally and doing something you don't get to do very often! With that being said, while this is a physical event, brains and collaboration are much more important than how fast can you get from one location to another. 

Good navigation skills, regardless of whether you're familiar with the area, are helpful. Choose a teammate that you communicate well with. Although you definitely don't need to be an athlete, you should be in reasonably good physical shape. Running is never required, however it is often advantageous.